Xiaozheng Lu; Zhijun Li; Yahui Liu; Zishuai Wang; Fenghui Peng; Qiong Yu; Xueqi Fu; Bai Ji
Volume 22, Issue 7 , 2020
Abstract
Context: Hepatocellular carcinoma (HCC) is a common malignant cancer and the second leading cause of cancer-related deaths around the world. Radiofrequency ablation (RFA) and laparoscopic hepatectomy (LH) have been adopted for the treatment of HCC. The aim of the meta-analysis was to explore the long-term ...
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Context: Hepatocellular carcinoma (HCC) is a common malignant cancer and the second leading cause of cancer-related deaths around the world. Radiofrequency ablation (RFA) and laparoscopic hepatectomy (LH) have been adopted for the treatment of HCC. The aim of the meta-analysis was to explore the long-term efficacy of RFA compared with LH for small HCC (sHCC) patients in the East Asian population.
Evidence Acquisition: We performed a systematic review and meta-analysis by the literature search on PubMed, Cochrane Library, EMBASE, Chinese Biological Medical Literature (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang from their inception until October 10, 2019, for comparing the long-term efficacy outcomes of RFA with LH.
Results: Fourteen retrospective studies with 1,390 subjects were included in the meta-analysis. Compared with the LH-treated group, RFA could raise the local recurrence rate under median follow-up duration and reduce disease-free survival (DFS) rates at 1 - 3 years. However, it failed to affect 5-year overall survival (OS) and DFS rates. In the subgroup analyses, different RFA approaches
had significantly higher local recurrence rates than the LH group. A similar effect on OS and DFS rates within five years for single early (? 3 cm) HCCs and on the 1- and 5-year DFS rates for nodules ? 5 cm were observed between the two groups, but RFA approaches could reduce the 3-y OS and DFS rates for single nodules ? 5 cm. The percutaneous radiofrequency ablation (PRFA) group had signif-icantly lower 3- and 5-year OS and the 1- and 3-year DFS rates than the LH group, while no significant difference in OS and DFS rates in the laparoscopic radiofrequency ablation (LRFA) approach. The RFA approach improved the 3-year OS compared with the LH group in Japan, but reduced the 3-year OS and DFS rates within 3 years in China.
Conclusions: Our results support that LH treating sHCC had a better long-term efficacy and a lower local recurrence rate than RFA in the East Asian population. Further high-quality prospective studies are required to confirm the long-term efficacy.
Guojun Kang; Shangchao Zhang; Yaqin Yu; Qiong Yu
Volume 21, Issue 9 , 2019, Pages 1-5
Abstract
Background: Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder. Several susceptibility genes were found in the genome-wide study of ASD. There are few reports of the association between granzyme B (GZMB) and ASD.Objectives: This study aimed to investigate the association between ASD ...
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Background: Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder. Several susceptibility genes were found in the genome-wide study of ASD. There are few reports of the association between granzyme B (GZMB) and ASD.Objectives: This study aimed to investigate the association between ASD and GZMB polymorphism in the northeast Han Chinese population.Methods: A case-control study was conducted in Changchun city, a northeast city of China, from June 2014 to November 2014. We enrolled 268 Han population Chinese children in a case-control study, including 85 ASD patients and 183 healthy controls. We also recruited 67 nuclear family trios. Three single-nucleotide polymorphisms (SNPs) (rs2236338, rs10873219, and rs8192917) were selected and genotyped. The association between the GZMB SNPs and ASD was analyzed using the Transmission Disequilibrium Test (TDT).Results: No statistical differences were found in allele and genotype frequency of the three SNPs of the GZMB gene between the case and control groups (all P > 0.05). Our study showed that rs2236338-rs10873219-rs8192917 G-T-G (P = 0.41) and G-G-G (P = 0.59) haplotypes were not associated with ASD. Moreover, TDT showed negative results (P = 0.885 for rs2236338, P = 0.900 for rs10873219, and P = 0.900 for rs8192917).Conclusions: There was no association between the three SNPs in GZMB and ASD. Further studies need to determine and verify the relationship between the GZMB gene and ASD.
Mingjia Yang; Yaqin Yu; Qiong Yu
Volume 19, Issue 8 , August 2017, , Pages 1-3
Abstract
Mental health is a private matter, which refers to an individual’s cognition and emotion; more precisely, it describes the condition of one’s mind. The slogan “no health without mental health” has been proposed by the world health organization (WHO) for a few years (1). According ...
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Mental health is a private matter, which refers to an individual’s cognition and emotion; more precisely, it describes the condition of one’s mind. The slogan “no health without mental health” has been proposed by the world health organization (WHO) for a few years (1). According to statistics, almost 450 million people suffer from mental or neurological diseases.
